Löffler’s Syndrome is a benign and self-limiting condition in which an allergic infiltration of eosinophils is seen in the lungs. This allergic reaction is most often due to drugs, such as sulfonamides, or infection with a fungus or parasite, including Ascaris lumbricoides (the giant roundworm of…
Eosinophilic Pneumonia… Maybe I’ll go over the parasite side soon? Only if I read up on it and promise not to balls it up this time…
Only a couple of posts in, and already I’ve ballsed up.
NK Cells are innate cells! Don’t know how I let that slip past me!
NK cells are of the lymphoid heritage, the same as B Cells and T Cells. However, they aren’t considered adaptive cells.
Many many thanks to http://svetlanasikorska.tumblr.com/ for pointing out my schoolboy error.
In the flow chart I’ve got in the tl;dr post; imagine I put Lymphocyte heritage instead of adaptive, and Myeloid heritage instead of innate. Then what is there would be correct (yup, it would be right if different)
Oh well! Posts will no longer be post without careful scrutiny, or whilst tired. Obviously as I thought I was on the basics I wouldn’t mess up… foolish…
p.s. We think of adaptive as adaptive as it has memory. NK cells have been recently shown to have memory. R Paust, S. et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nature Immunol. 24Oct 2010 (doi:10.1038/ni1953)
Phagocytosis: Eat them alive and wash them down with Chlorine.
Phagocytosis goes on all over the body, all the time. When cells die and need to be removed, they’re often mopped up through this.
It happens much more though, in times of infection and inflammation.
Phagocytes have a simple approach to infection; take cells in and destroy them with as many chemical and enyzymatic processes as possible. Not so far away from dumping what you want to get rid of in a bucket and pouring all the bleach you can find on it.
>Can tell the difference between self and non-self (what’s ‘you’ and what’s everything else)
>Can tell which non-self components are dangerous (which things floating around in your intestine are cornflakes, and which are the cholera that came along for the ride)
>Removes (or at least attempts to remove) anything that it deems dangerous.
(EDIT: In the chart below, NK Cells should come under the innate heading. It’s wrong due to an absentminded mistake of mine. NK cells come from the same cells as B and T cells; they’re of the lymphoid heritage. Rather than the myeloid heritage that the rest of the innate cells come from. However, they are still considered innate rather than adaptive.)
Think of the post below as a reference, from now on posts will be shorter and a bit less text heavy. It’ll also be more detailed. (Shorter and more detailed? = Distilled Science…)
Oh! and there’ll be bloody loads of pictures too, not just mind-maps…
Cells in the Immune System - who they are and what they get up to... (EDITED)
How do infections take over a person? How do they cause entire countries to collapse? How do they spread across the world? Perhaps the more important question would be, why don’t they do that all the time?
Why do we find HIV killing millions when the cold gets far less impressive figures? Why do we find that one strain of flu causes mass panic when we live relatively comfortably with so many others?
The obvious reason is this; we have defense systems. These systems are separate in many ways, but they act together and come under a collective term, the immune system.
The immune system:
Can tell the difference between self and non-self (what’s ‘you’ and what’s everything else)
Can tell which non-self components are dangerous (which things floating around in your intestine are cornflakes, and which are the cholera that came along for the ride)
Removes (or at least attempts to remove) anything that it deems dangerous.
By describing the immune system and it’s tactics; we can understand how infections attempt to find weak points in the system, or how they use their own strengths to take hold in our bodies. Firstly, we should describe what the immune system is, before we can describe what it does.
So, what’s going to get looked at over the next little while? (I did enough of my own work today so I get to think about this!) I thought, to avoid being a one post and gone kinda affair, it’d help if I had a plan.
I want to start basic, that those who’ve not had an intro to immunology will be able to follow this all the way through. We’re going to cover wide areas of science, but with very few assumptions as to what people already know. So sorry if you’ve already got a reasonable grasp of this all, but this can just reinforce your knowledge; and there’ll be decent examples later on which may be new for you.
Above were some rough ideas put together quickly. As you could guess, the first ‘proper’ post will be an intro to immunology in general, and why it matters.
In fact, I’m going to stop procrastinating, and go and write it. Got to start at some point yeah?
Yes, I realise it’s pretty daft that I keep using the plural, the idea that there’s a ‘we’ to go over these ideas together isn’t true. But just in case…
My personal reasons for writing are in the post below, but why would you care about those? Content’s what matters.
Well the content will be looking at; medicine, parasitology, microbiology, virology, global health, and global politics through a certain lens.
The posts should allow anyone to understand these subjects above with only the tiniest amount of prior knowledge. Hopefully I’ll explain these topics in such a way that enthusiastic school kids should grasp; and those with greater understanding shouldn’t find them too basic.
So that’s why this blog exists, now why this title in particular? Well it’s partly as I had to think of one the second I chose to register, but it does highlight the subject.
Human bodies are constantly under attack, sometimes just from other bodies, but I’m thinking of a more zoomed in level. We have, over several million years, developed our immune system. This system of self defence protects us against intruders of all forms; who attack in ways I hope to describe in later posts. As quite a complicated and convoluted system; it can fail. Hopefully I’ll describe instances of that as well.
So in ‘Everything Versus Host’, I really do mean everything. We’ll cover viruses, bacteria, and parasites. We’ll also look at more weird situations, like what goes on with snake bites. There’ll also be a bit of host versus host, with autoimmunity in all its forms.
With these subjects we’ll start at a relatively basic point, but build it up to where we’ll push at the levels of current research.
and of course, when lazy, we’ll just link to other interesting articles.
This won’t be a updating more than once a week, if it does it’ll mean I’m procrastinating a bit too much and someone should get me back to my own revision. Over the next few days I’ll post my first ideas for topics (obviously, we’ve a lot of basics to start with).